show Abstracthide AbstractStreptococcus suis is a major swine pathogen responsible for important economic losses to the swine industry worldwide. It is also an emerging zoonotic agent of a meningitis and streptococcal toxic shock-like syndrome. Since the recent recognition of the high prevalence of S. suis human disease in southeast and east Asia, the interest of the scientific community in this pathogen has significantly increased. In order to cause disease, S. suis must colonize the host, breach epithelial barriers, reach and survive in the host bloodstream, invade different organs, and cause exaggerated inflammation.In this project, we would like to analyze and compare in detail the S. suis isolates from pigs and porcine lesions by using NGS. This data can find solutions for the issues of S. suis.